Course Outline

1. In vivo, in vitro, in silico, Proteins, Protein structure and conformation: Basic concepts, Proteins in diseases
2. Patterns and forms in protein structure, Helices and sheets, The hierarchical nature of protein architecture, Structure based classification of proteins protein folding: Intra-cellular pathogens and the survival of the flattest, Protein folding and disease: Amyloidoes, Parkinson, Huntington, Prion disease
3. Conformational changes in protein, Structural changes arising from changes in state of ligation, Hinge motions in proteins, Mechanisms of conformation changes (Haemoglobin, Serpins,muscle contraction), Higher level structural changes (GroELS)
4: Protein Structure Prediction and Determination, Methods of protein structure determination, Critical assessment of structure prediction, Homology modelling, Threading, Prediction of novel folds, Protein design
5. Evolution of Protein Structure and Function, Protein structure classification, Structural relationships among homologous proteins, Changes in proteins during evolution uncovers functionally/structurally important amino acid sites, Domain swapping, Classification of protein folding patterns, How do proteins evolve new functions?, Classification of protein functions
6. Molecular evolution, Evolution of Globins, Evolution of Serine proteinases, Evolution of visual pigments and related molecules)
7. Molecular Coevolution and mutation epistatic effects on protein structure, Defining molecular coevolution, Nonparametric methods to detect coevolution, Parametric methods to detect coevolution, Intramolecular coevolution and prediction of amino acid sites threedimensional proximity, Interprotein coevolution and the identification of protein protein interfaces
8. Some examples of the immune system, Antibody structure, Protein of the Major histocompatibility Complex, T-cell receptors, Cancer and protein structures

Course Outline

1. Darwin, Theory of Evolution, Darwin and society
2. Genetic Variability, Allele Frequency
3. Hardy Weinberg Equilibrium, Selection, Mutation, Migration, Genetic Drift, Non random mating
4. Speciation
5. Mechanisms of divergence, Genetic drift, natural selection, sexual selection, reinforcement selection
6. Molecular evolution, Neutral theory of molecular evolution
7. Molecular phylogenetics
8. Phylogeny and sequence comparison
9. Evolution of development
10. Human Evolution.