This server provides an online interface to CAPS, a Perl program that performs Coevolution Analysis using Protein Sequences, i.e. it searches through a set of homologous sequences and detects groups of amino acids that evolve together. The results can indicate functionally or structurally linked regions that are subjected to strong selective constraints.

This website is free and open to all users and there is no login requirement.


If you use CAPS in your research, please include the following citation:

CAPS: coevolution analysis using protein sequences.
Fares MA, McNally D.
Bioinformatics. 2006 Nov 15;22(22):2821-2.
PMID: 17005535

The mathematical model has been described separately:
A novel method for detecting intramolecular coevolution: adding a further dimension to selective constraints analyses.
Fares MA, Travers SA.
Genetics. 2006 May;173(1):9-23.
PMID: 16547113


Funding and support from the following resources allowed this project to be realised:
Science Foundation Ireland Principal Investigator Award
Trinity College Dublin, Ireland
Smurfit Institute of Genetics